Ending Medical Reversal by Vinay Prasad (MD MPH) and Adam Cifu (MD) is an essential book for medical students, physicians, and anyone even peripherally involved in medicine; for everybody else, it's merely highly recommended. The core of the book, paraphrasing, is that sometimes physicians decide to do things to patients without great evidence. These practices are, later on, 'reversed' by well-done trials, often to the great surprise of thought leaders and experts in a specialty. This is "
Book Review: Ending Medical Reversal
Humanized mouse models, or organ (systems) on a chip are the real solution.